Non-Hodgkin's lymphoma (NHL) is a cancer disease affecting the lymphatic system, which actually depends on the immune system. The structure of the lymphatic system are the vessels that moves fluid - lymph containing cells - protective cells. In the system of blood vessels are the lymph nodes, small organs distributed throughout the body and reproduce cells. Besides the above listed, the lymphatic system include the tonsils, thymus, skin, small intestine, spleen and bone marrow.

   Designating two types of lymphocytes: B lymphocytes (B cells) and T lymphocytes (T-cells). B cells produce antibodies that fight disease-causing bacteria, the T-lymphocytes - recognize and destroy virus-infected and tumor cells. Hodgkin's lymphoma develops when there is an error in the synthesis of lymphocytes and there antomalnye T-and B-cells (usually B-lymphocytes). These cells develop faster than normal and do not die when the time comes. Malignant cells do not protect the body from infections and other diseases. This process creates a mass of tissue called a tumor. The share of B-cell lymphomas account for 85% of the cases, T-cell - 15%. Allocate 29 types of NHL.

Risk factors of a Non-Hodgkin lymphoma

  Doctors can seldom tell why at one person NHL illness, and at another - No. develops. But researches show that certain risk factors increase risk of development of an illness:

   The weakened immune system of the person, for example, in connection with a hereditary disease or reception of some medicines after an organ transplantation.

  Infections increase risk of development of a lymphoma. Nevertheless the illness on is infectious, it is impossible will catch it from other person. The main types of an infection increasing probability of a disease:

  • Human Immunodeficiency Virus (HIV).
  • Epstein's virus - Barrel
  • Helicobacter pylori - a bacterium causing stomach ulcer.
  • T-limfotropny a virus of the person of type 1 - HTLV-1 Ц increases risk of development of the T-cellular lymphoma and a leukosis.
  • Hepatitis C virus: a number of researches showed the increased probability of emergence of a lymphoma at the people having a virus of hepatitis of Page

   Age: the majority of cases is the share of age group after 60 years.

   Excess weight or obesity.

  Contact with herbicides, insecticides, benzene.

Symptoms of a Non-Hodgkin lymphoma

  The illness can have a set of signs:

  • painful increase in lymph nodes on a neck, in axillary hollows or a groin;
  • inexplicable weight reduction;
  • the increased body temperature;
  • excessive perspiration at night;
  • the cough, the complicated breath or a breast pains;
  • weakness and fatigue;
  • feeling of a full stomach, pain in a stomach.

Non-Hodgkin lymphoma: diagnostics in Israel

  In the Israeli clinics it is carried out the following types of inspections:

  • Collecting the anamnesis and medical examination Ц the doctor checks increase in lymph nodes in a groin, on a neck, in armpits, the spleen or liver sizes.
  • Laboratory researches: blood analyses. In the general analysis of blood the quantity of white cages is counted, the content of other substances also is checked, for example, the lymphoma can cause the raised level lactate dehydrogenase (LDH).
  • X-ray research: it is surveyed the increased lymph nodes and other symptoms of an illness in a breast.
  • The biopsy is the only reliable method of diagnostics of a lymphoma. The ekstsizionny biopsy in the course of which completely delete the affected lymph nodes in a certain area can be applied or only the part is an intsizionny biopsy. On the basis of this inspection the type of a lymphoma is defined.

  There are many types of a lymphoma, but the diffusion V-cellular lymphoma and a follicular lymphoma are the most widespread.

Lymphoma also can be grouped according to growth of their speed:

  • Nonaggressive or lazy lymphoma with low degree of a malignancy.
  • The aggressive lymphoma grows and extends quicker, causes heavy symptoms.

  To define a stage of a Non-Hodgkin lymphoma and to pick up the best option of treatment additional inspections are necessary for the examination, what bodies and sites of a body suffered from a disease.

  • The marrow biopsy Ц by means of a thick needle is taken a small sample of marrow from a pelvic bone or other big bone.
  • The computer tomography Ц is conducted research in the head, a neck, a breast, a stomach or a basin, sometimes with application of contrast liquid.
  • MRT: the backbone, bone or a brain about distribution of malignant process can be investigated.
  • PET-KT helps to reveal metastasises, intravenously to the patient enter solution with a radioactive isotope of glucose. The struck sites absorb contrast in bigger quantity. The detailed images specify a pas the struck areas.

Non-Hodgkin lymphoma: lymphoma stages

   The I stage Ц is struck one group of lymph nodes (for example, a neck or axillary area) or the illness affected one body or fabric (for example, lungs or bone fabric).

   The II stage Ц cages of a lymphoma are at least in two lymph nodes on one party of a diaphragm or on one party of body and lymph nodes of this body.

  The III stage Ц lymph nodes above and lower than a diaphragm are struck, also abnormal cages can find on one party of fabric or body near these groups of lymph nodes.

  The IV stage Ц cages of a lymphoma strike other bodies Ц a liver, bone fabric, etc.

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